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人乳头状瘤病毒(HPVs)可导致皮肤或粘膜的增生性改变。这些增生大多为良性病变,但有一些则可为恶性,这种转化多与HPV的类型有关。现已知HPV16不仅与宫颈癌有关,而且与喉癌、肺鳞癌和食管癌有关。本文利用生物素标记HPV6,11,16,18DNA探针,对10例组织学诊断为支气管粘膜鳞状化生和33例分化良好的支气管鳞癌的石蜡切片进行严格条件下的原位杂交(19℃温度条件下)。
Human papilloma viruses (HPVs) can cause proliferative changes in the skin or mucous membranes. Most of these hyperplasia is a benign lesion, but some may be malignant, and this type of transformation is mostly associated with HPV. It is known that HPV16 is not only associated with cervical cancer, but also with laryngeal cancer, squamous cell carcinoma and esophageal cancer. In this study, biotinylated HPV6, 11, 16 and 18 DNA probes were used to perform in situ hybridization on 10 paraffin-embedded tissues of bronchial squamous metaplasia and 33 well-differentiated bronchial squamous carcinomas (19 ℃ temperature conditions).