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  5. In vitro and in vivo evaluation of cucurbitacin E on rat hepatic CYP2C11 expression and activity us

In vitro and in vivo evaluation of cucurbitacin E on rat hepatic CYP2C11 expression and activity us

来源 :中国科学：生命科学英文版 | 被引量 : 0次 | 上传用户：yanqingilu
【摘 要】
：
This study explored the effects of cucurbitacin E(Cu E), a bioactive compound from Cucurbitaceae, on the metabolism/ pharmacokinetic of tolbutamide, a model CYP
【作 者】
：
Jian Lu Tonggui Ding Xuan Qin 
【机 构】
：
ShanghaiKeyLaboratoryofRegulatoryBiology
【出 处】
：
中国科学：生命科学英文版
【发表日期】
：
2017年2期
【关键词】
：
LC-MS/MS 生物活性化合物 大鼠肝 葫芦素 体内 体外 药代动力学 竞争性抑制 cucurbitacin E  CYP2Cll  LC-MS/MS  ph 
【基金项目】
：
supported by the National Natural Science Foundation of China (81301908),,the Science and Technology Commission of Shanghai Municipality (13ZR1412600, 14DZ2270100)
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论文部分内容阅读
This study explored the effects of cucurbitacin E(Cu E), a bioactive compound from Cucurbitaceae, on the metabolism/ pharmacokinetic of tolbutamide, a model CYP2C9/11 probe substrate, and hepatic CYP2C11 expression in rats. Liquid chromatography-(tandem)
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