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目的探讨羊水细胞染色体分析在产前诊断中的重要价值。方法无菌条件下,取羊水细胞培养,常规收获,G显带,镜下核型分析。结果符合产前诊断指征成功培养的1430例羊水染色体中,共检出异常核型67例,检出率为4.68%,其中三体综合征25例,占异常染色体检出总数的37.3%,性染色体异常11例,占16.4%。平衡易位9例,占13.4%。其他异常22例。结合临床资料对异常染色体进行分析。结论羊水细胞染色体检查是目前安全,有效,最可靠的诊断胎儿染色体病的方法。
Objective To investigate the value of amniotic fluid cell chromosome analysis in prenatal diagnosis. Methods Aseptic conditions, take amniotic fluid cell culture, routine harvest, G band, microscopic karyotype analysis. Results A total of 1430 cases of amniotic fluid chromosome were successfully cultured in accordance with the prenatal diagnosis indications. A total of 67 abnormal cases were detected, the detection rate was 4.68%, of which 25 cases were trisomy syndromes, accounting for 37.3% of the total number of abnormal chromosomes detected. 11 cases of sex chromosome abnormalities, accounting for 16.4%. 9 cases of balanced translocation, accounting for 13.4%. Other abnormalities in 22 cases. Abnormal chromosomes were analyzed with clinical data. Conclusion Chromosome examination of amniotic fluid cells is the safe, effective and reliable method to diagnose fetal chromosomal diseases.