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本文对某PVC厂生活区空气VC污染状况及人群健康效应进行了调查,结果表明:空气质量指数(I_1)>1.50,空气质量属中度污染,此时氯乙烯(VC)≥0.17mg/m~3,10～14岁儿童血清溶菌酶(S-LZM)活性明显增高(12.34μg/ml,萤光法);而成人的S-LZM活性也增高(15.31μg/ml,比浊法),且T细胞转化率明显降低(72.9％),人群出现免疫效应;VC>4.0mg/m~3(I_1>2.0),空气质量属极重污染,成人染色体总断裂率明显增高(5.6％、G显带),呈现细胞遗传毒性;VC>25.0mg/m~3时,SCEs达9.08。并且发现效应有随接触VC量的增加而加重的趋势。研究还证明:I法评价空气环境质量比较合理,G显带染色体分析术对致突变物的环境流行病学调查有实用性。
The results showed that the air quality index (I_1)> 1.50, the air quality was moderate pollution, the VC (VC) ≥0.17mg / m The serum L-lysine (S-LZM) activity was significantly increased in children aged 10 to 14 years (12.34μg / ml, fluorescence method); while the activity of S-LZM in adults was also increased (15.31μg / ml) (T (72.9%)). The population showed immune effect. VC> 4.0mg / m ~ 3 (I_1> 2.0), the air quality was extremely polluted, and the total chromosome rupture rate in adult was significantly increased (5.6%, G Show band), showing cytogenetic toxicity; VC> 25.0mg / m ~ 3, SCEs up to 9.08. And found that the effect with the amount of exposure to VC increased the trend of aggravating. The study also proves: I method to assess the air quality is reasonable, G-banding chromosome analysis of the mutagen environmental epidemiological investigation of practical.