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目的探讨脉冲Nd:YAG激光照射唇部静脉湖后热传输的特点,提供脉冲Nd:YAG激光作用唇部静脉湖后组织热效应的有效预测平台。方法建立唇部静脉湖有限元分析模型,模拟不同照射时间下(2s、3s、5s、7s)Nd:YAG激光照射唇部静脉湖模型后的温度响应。建立Nd:YAG激光照射唇部静脉湖生物模型,获取激光照射过程中生物模型温度的变化规律,验证有限元分析模型的准确性。结果理论模型显示,随着照射时间的延长,距离照射点轴向3mm处的温度呈曲线上升。在不考虑血液灌注的情况下,2s、3s、5s、7s时的温度分别为(51±0.12)℃、(56±0.20)℃、(77±0.20)℃、(90±0.12)℃(P<0.05)。生物模型显示,随着照射时间的延长,距离照射点轴向3mm处的温度呈曲线逐渐上升,在7s时的温度为(90±0.20)℃,实际温度变化曲线和不考虑血液灌注的理论曲线基本吻合(P>0.05)。结论有限元分析模型可以比较好地预测组织的反应,对于研究激光治疗血管性病变有一定的参考价值。根据有限元分析模型结果提示,临床治疗唇部静脉湖中应注意单点照射时间不宜超过7s,以免造成组织不可逆的热损伤。
Objective To investigate the characteristics of heat transfer after pulsed Nd: YAG laser irradiation of lacustrine vein and to provide an effective prediction platform for tissue thermal effects after pulsed Nd: YAG laser irradiation on lacustrine vein. Methods The model of lip venous lake was established and the temperature response of the model of lip venous lake irradiated by Nd: YAG laser (2s, 3s, 5s, 7s) was simulated under different irradiation time. The Nd: YAG laser irradiation model of lip venous lake was established, and the change rule of biological model temperature during laser irradiation was obtained. The accuracy of finite element analysis model was verified. The results of the theoretical model show that with the extension of the irradiation time, the temperature at a distance of 3 mm from the irradiation point increases in a curve. Without blood perfusion, the temperatures at 2s, 3s, 5s and 7s were (51 ± 0.12) ℃, (56 ± 0.20) ℃, (77 ± 0.20) ℃, (90 ± 0.12) ℃ <0.05). The biological model showed that with the extension of irradiation time, the temperature at 3mm from the irradiation point gradually increased curve, the temperature was (90 ± 0.20) ℃ at 7s, the actual temperature curve and the theoretical curve without considering blood perfusion Basically consistent (P> 0.05). Conclusion Finite element analysis model can better predict the tissue response, which has some reference value for the study of laser treatment of vascular lesions. According to the finite element analysis model results suggest that clinical treatment of lip venous lake should pay attention to a single point of irradiation time should not exceed 7s, so as to avoid tissue irreversible thermal damage.