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本文报告了女性外用避孕药膜主要成分烷苯聚醇醚（ＡＰＰＥＥ）致癌性的研究。ＴＲ２大鼠，每周局部放置药膜１次，连续给药１ａ，共观察２ａ．ＡＰＰＥＥ１１，３３和１００ｍｇ·ｋｇ－１组，阴道及宫体部位的恶性肿瘤发生率分别为２．０％，６．０％及１７．４％，后者与对照组相比．差异非常显著（Ｐ＜０．０１）．非阴道及宫体部位的恶性肿瘤发生率分别为１０．２％，１０．０％及２１．７％。１００ｍｇ·ｋｇ－１组与对照组相比差异显著（Ｐ＜０．０５）．实验结果表明：长期应用ＡＰＰＥＥ避孕药膜除对大鼠阴道及宫体用药局部有致癌作用外，不能完全排除对全身的致癌性．
This article reports the carcinogenicity of APPEE, a major component of female topical contraceptive film. TR2 rats, local drug film placed once a week, continuous administration 1a, were observed 2a. The incidences of malignant tumors in the APPEE11, 33 and 100 mg · kg-1 groups were 2.0%, 6.0% and 17.4%, respectively, in the vagina and the uterine body, compared with the control group. The difference was significant (P <0.01). Non-vaginal and uterine parts of the incidence of malignant tumors were 10.2%, 10.0% and 21.7%. 100mg · kg-1 group compared with the control group, the difference was significant (P <0.05). Experimental results show that: long-term use of APPEE contraceptive film in addition to the vaginal and uterine body parts of rats have carcinogenic effects, can not be completely ruled out the carcinogenicity of the body.