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目的 探讨内皮素 - 1 (Endothelia- 1 ,ET- 1 )和白细胞介素 - 6(IL - 6)在儿童哮喘发病机理中的作用。方法 采用放免法对 35例支气管哮喘患儿和 2 0例正常儿童进行了血浆 ET- 1及血清 IL- 6水平检测。结果 哮喘急性期患儿血 ET- 1明显高于缓解期 (P <0 .0 1 ) ,缓解期 ET- 1虽有所下降 ,但仍高于对照组 (P <0 .0 5) ,IL- 6水平与对照组相比无显著差异 (P >0 .0 5)。结论 ET- 1水平与哮喘病情严重程度成正相关 ,是反映哮喘严重程度的良好指标。哮喘患儿病情严重者 IL- 6明显升高 ,随着临床症状的好转 ,IL- 6也随之降低 ,IL- 6在哮喘发病机理中起重要作用
Objective To investigate the role of Endothelia-1 (ET-1) and interleukin-6 (IL-6) in the pathogenesis of childhood asthma. Methods 35 patients with bronchial asthma and 20 normal children were tested for plasma ET-1 and serum IL-6 by radioimmunoassay. Results ET-1 in acute asthmatic children was significantly higher than that in remission (P <0.01), ET-1 in remission was still lower than that in control group (P <0.05), IL - 6 levels compared with the control group no significant difference (P> 0.05). Conclusions The level of ET-1 is positively correlated with the severity of asthma and is a good indicator of the severity of asthma. IL-6 is significantly elevated in asthmatic children with severe illness, IL-6 also decreases with the improvement of clinical symptoms, and IL-6 plays an important role in the pathogenesis of asthma