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目的研究绝经后2型糖尿病(T2DM)患者的性激素结合球蛋白(SHBG)与动脉粥样硬化(AS)危险因子的相关性。方法绝经后T2DM患者45例(20例合并大血管并发症,25例无大血管并发症),测定SHBG、FPG、FIns、FC-P、TC、TG、HDL-C、LDL-C、纤维蛋白原(FIB)。以ISI=-Ln(FPG·FIns)作为胰岛素敏感性指标。对SHBG与BMI、WHR、FPG、FIns、FC-P、ISI、脂代谢指标、FIB的相关性进行分析。结果有大血管并发症组SHBG、ISI显著低于无大血管并发症组,而WHR、FPG、FIns、FC-P、TC、LDL-C、FIB显著高于无大血管并发症组。在简单相关分析中,SHBG与ISI呈显著正相关(R=0.731,P<0.01)。在逐步回归分析中,FC-P为预测SHBG最强的指标。结论低水平的SHBG是绝经后2型糖尿病患者动脉粥样硬化的危险因素之一。
Objective To investigate the association between sex hormone binding globulin (SHBG) and atherosclerosis (AS) risk factors in postmenopausal type 2 diabetes mellitus (T2DM). Methods Forty-five patients with T2DM (20 patients with macrovascular complications and 25 patients without macrovascular complications) were enrolled in this study. The levels of SHBG, FPG, FIns, FC-P, TC, TG, HDL-C, LDL- Original (FIB). ISI = -Ln (FPG · FIns) as an indicator of insulin sensitivity. The correlation between SHBG and BMI, WHR, FPG, FIns, FC-P, ISI, lipid metabolism index and FIB was analyzed. Results The SHBG and ISI were significantly lower in patients with macrovascular complications than those without macrovascular complications. WHR, FPG, FIns, FC-P, TC, LDL-C and FIB were significantly higher than those without macrovascular complications. In the simple correlation analysis, there was a significant positive correlation between SHBG and ISI (R = 0.731, P <0.01). In a stepwise regression analysis, FC-P is the strongest predictor of SHBG. Conclusion Low-level SHBG is one of the risk factors for atherosclerosis in postmenopausal type 2 diabetic patients.