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目的 探讨脑血管病患者死亡时间的昼夜节律变化特点和规律。方法 回顾性分析脑血管病死亡患者临床资料 ,重点分析死亡时间 ,利用圆形分布的统计方法 ,计算出死亡高峰时刻和 2 4h内 95 %的死亡时间集中时段。结果 脑血管病患者死亡高峰时刻为清晨 5时 5 9分 ,2 4h内 95 %的死亡时间发生在前一日 2 0时 2 1分至当日 1 5时 37分 ;出血性脑血管病患者死亡高峰时刻为 6∶2 0 ,95 %的死亡时间发生在 1时 4 0分至 1 1时 0 1分 ;缺血性脑血管病患者的死亡高峰时刻为清晨 5时 5 9分 ,2 4h内 95 %的死亡时间发生在凌晨 1时 0 4分至当日上午 1 0时5 4分。结论 脑血管病患者死亡时间有一定的昼夜节律分布特点 ,清晨通常为死亡的高峰时段 ,与机体血栓性病理状态恶化或血压的昼夜波动有关 ,但对于死亡时间的认识还要结合患者个体差异和治疗情况。工作中应注意加强夜间和凌晨患者的管理和监测 ,必要时改变投药时间 ,最大限度地减少死亡率
Objective To investigate the characteristics and patterns of circadian rhythm of death in patients with cerebrovascular disease. Methods The clinical data of patients who died of cerebrovascular disease were retrospectively analyzed. The death time was analyzed emphatically. Using the statistical method of circular distribution, 95% of the concentrated time of death were calculated at the peak of death and within 24 hours. Results The peak time of death of patients with cerebrovascular disease was 5:59 am and 95% of deaths within 24 hours occurred from 21:21 of the previous day to 15:37 of the same day. The death of patients with hemorrhagic cerebrovascular disease The peak time was 6: 20 and 95% of the deaths occurred between 1: 40 and 11: 0. The peak time of death in patients with ischemic cerebrovascular disease was 5:59 am and within 24 hours Ninety-five percent of the deaths occurred at 0:04 a.m. to 104 a.m. on the same day. Conclusions The death time of patients with cerebrovascular disease has some characteristics of circadian rhythm distribution. Early morning is usually the peak period of death, which is related to the worsening of thrombotic pathology or the fluctuation of blood pressure day and night. However, the understanding of death time should be combined with individual differences and Treatment situation. At work, care should be taken to strengthen the management and monitoring of patients at night and in the early hours, to change the dosage schedule when necessary, and to minimize mortality