【摘 要】
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Dear Editor,rnAutism spectrum disorders (ASDs) are neurodevelopmen-tal disorders with phenotypic and genetic heterogeneity,and are among the most heritable of neurodevelopmental disorders[1].Rare single nucleotide variants (SNVs) of genes and/or rare copy
【机 构】
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Institutes of Biomedical Sciences,Fudan University,Shanghai 200032,China;Department of Pathology,Sch
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Dear Editor,rnAutism spectrum disorders (ASDs) are neurodevelopmen-tal disorders with phenotypic and genetic heterogeneity,and are among the most heritable of neurodevelopmental disorders[1].Rare single nucleotide variants (SNVs) of genes and/or rare copy number variants (CNVs) involving gene variants and/or genomic imbalances play an important role in ASD,but their molecular pathogenic mechanisms remain indistinct[2].Over the decades,genetic andneurobiological studies mainly involving severe ASD comorbid with intellectual disability (ID) or developmental delay (DD) have indicated that loss of function affects neural development [3].
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