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目的探讨急性脑梗死(ACI)患者血清C反应蛋白(CRP)的含量变化及其临床意义。方法随机选择80例急性脑梗死患者,采用液相免疫沉淀散射比浊法对患者检测血清CRP水平,按梗死灶大小分组观察,并对其神经功能缺损进行标准评分。结果急性脑梗死不同梗死灶组比较,大小梗死组卒中后5～7d水平最高,随后逐渐下降,两组均较腔梗组为高(P<0.01);不同临床分型组间比较,重型组明显高于中型、轻型组、(均P<0.01)。结论血清CRP水平增高与急性脑梗死发生、梗死灶大小和严重程度关系密切、CRP可考虑作为急性脑梗死患者评估病情的指标之一。
Objective To investigate the changes of serum C-reactive protein (CRP) in patients with acute cerebral infarction (ACI) and its clinical significance. Methods Eighty patients with acute cerebral infarction were randomly selected. Serum CRP levels were measured by liquid immunoprecipitation and nephelometry. The infarct size was divided into groups and scored for neurological deficits. Results Compared with the infarction group, the infarct size in the infarcted group was the highest at 5 ~ 7d after stroke, and then decreased gradually in both groups (P <0.01). Compared with the severe group Obviously higher than the medium, light group, (all P <0.01). Conclusion The elevated serum CRP level is closely related to the occurrence of acute cerebral infarction and the size and severity of infarction. CRP may be considered as one of the indicators to evaluate the severity of acute cerebral infarction.