论文部分内容阅读
心先安的化学名称为环磷酸腺苷葡甲胺(简称:葡甲胺-cAMP),是一种国内外文献中尚未见报道的新化合物。它是迄今所找到的对病窦综合征有良效的新药,也是一种非强心苷类的强心药物。 心先安的整个研究工作,由徐州医学院原制药厂实验室和徐州医学院生物化学研究室承担,赵升皓副教授负责主持。1979年完成了该化合物的合成、理化性质、质量标准草案和部分药理实验,以及在徐州医学院附属医院进行的小规模临床实验。环磷酸腺苷(cAMP)与葡甲胺结合所形成的化合物,出现一些有实用意义的特性,其中包括:①心先安分子中的cAMP的稳定性增
Xin Xiangan chemical name is cyclic adenosine monophosphate meglumine (abbreviation: meglumine-cAMP), is a new compound has not been reported in the literature. It is by far found a good new drug for sick sinus syndrome, but also a non-cardiac glycosides cardiac drug. The heart of the first study of the entire work by the former Xuzhou Medical Laboratories Laboratory and Xuzhou Medical Biochemistry Laboratory commitment, Zhao Shenghao associate professor responsible for hosting. The compound was synthesized in 1979, the physical and chemical properties, the draft quality standards and some pharmacological experiments, and Xuzhou Medical College Hospital, a small-scale clinical trials. There are some practical properties of compounds formed by the combination of cAMP and meglumine, including: (1) the increase in the stability of cAMP in pro-AMP molecules