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女,14岁,因右股部蔓状血管瘤第14次接受平阳霉素注射治疗。注射方法:在胸透及血象检查正常情况下,取平阳霉素8mg溶解于注射用水2ml,抽0.2ml皮内注射,观察半小时无不良反应后,将已溶解的平阳霉素注入瘤体内每隔14天注射一次。本次用药1分钟后出现口舌和全身麻木,双眼失明,旋即口唇及全身皮肤颜色发绀,畏寒,恶心、呕吐胃内容物2次,腹痛。查体:P56次/分、R18次/分、Bp13/9kPa。意识清楚,全身皮肤青紫。双瞳孔等大等圆、直径2mm,眼前指动,光感消失。双肺、腹部正常。神经系统:病理反射未引出。立即给予非那根25mg肌注,5%葡萄糖500ml+地塞米松10mg静滴,6分钟后视力恢复正常,但球结膜充血明显,全身肤色微红,余症状缓解。30分钟后,球结膜充血明显减轻,全身肤色、恢复正常。1小时后,除精神欠佳外,余均恢复正常。
Female, 14 years old, receiving Pingyangmycin injection for the fourteenth time due to the right femoral hemangioma. Injection method: chest X-ray and blood test under normal circumstances, taking Pingyangmycin 8mg dissolved in water for injection 2ml pumping 0.2ml intradermal injection, the observation of half an hour no adverse reactions, the dissolved bleomycin injection into the tumor every Injections every 14 days. 1 minute after the medication appears tongue and numbness, blindness, immediately lips and body color cyanosis, chills, nausea, vomiting stomach contents 2 times, abdominal pain. Physical examination: P56 beats / min, R18 beats / min, Bp13 / 9kPa. Consciousness, the whole body bruising. Double pupil and other large round, diameter 2mm, immediate action, light disappeared. Double lungs, abdomen normal. Nervous system: pathological reflex did not lead. Immediately given intramuscular injection of phenanthrene 25mg, 500ml of dexamethasone 5% dextrose 500ml + intravenous infusion of 6 minutes after the visual acuity returned to normal, but conjunctival hyperemia significantly, body color reddish, remaining symptoms ease. After 30 minutes, conjunctival hyperemia was significantly reduced, body color, returned to normal. After 1 hour, except for being in poor condition, I was back to normal.