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目的：探讨人胆管癌细胞中ＬＮ和ＬＮ—Ｒ的表达水平与胆管癌转移的关系。方法：应用 Ｓ—Ｐ免疫组化法 对５２例人胆管癌细胞中ＬＮ和 ＬＮ－Ｒ的表达水平进行研究。结果：ＬＮ及 ＬＮ－Ｒ高表达与胆管癌淋巴结转移至明显 相关， ＬＮ及 ＬＮ—Ｒ阳性肿瘤淋巴结转移率（８３％，５５％）明显高于ＬＮ—Ｒ阴性肿瘤（１５％，２０％，Ｐ＜０．０５），且ＬＮ及 ＬＮ—Ｒ 的表达与胆管癌组织学类型、分化程度亦存在明显相关（Ｐ＜０．０５）。结论：ＬＮ及ＬＮ—Ｒ的表达在胆管癌淋巴结转移中 的关系起联合作用。
Objective: To investigate the relationship between the expression of LN and LN-R and the metastasis of cholangiocarcinoma in human cholangiocarcinoma cells. Methods: S-P immunohistochemistry was used to study the expression of LN and LN-R in 52 human cholangiocarcinoma cells. Results: The high expression of LN and LN-R was significantly associated with lymph node metastasis of cholangiocarcinoma. The lymph node metastasis rate of LN and LN-R positive tumors (83%, 55%) was significantly higher than that of LN-R negative tumors (15%, 20%, P<0.05), and the expression of LN and LN-R were also significantly associated with the histological type and differentiation of cholangiocarcinoma (P<0.05). Conclusion: The expression of LN and LN-R plays a joint role in the lymph node metastasis of cholangiocarcinoma.