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目的探讨药物定量脑电图在重症脑梗死治疗中的临床应用价值。方法 60例首次发病的重症脑梗死患者,随机分为两组,A组使用桂哌齐特治疗,B组不使用桂哌齐特治疗,而使用常规治疗。每组患者均使用数字化脑电图16导单极采样,分别于治疗前、治疗后1d,3d,7d,14d以及21d行脑电监测,分析各个脑区的δ和θ频段的相对功率值。并对患者在同一时间行NIHSS评分。结果 A组患者和B组患者在治疗前后的不同时期NIHSS评分是没有明显差异性的,但是从脑电上看,在治疗后d14,A组患者的前额区、患侧中颞区δ频段的相对功率值明显低于对照组(P﹤0.05)。治疗后d21,A组患者的各个脑区δ频段的相对功率值亦较B组明显降低,两者比较差异有统计学意义(P﹤0.05)。A组患者在治疗后d7前额区、患侧中央区、颞区、枕区θ频段的相对功率值明显低于对照组患者,两者比较差异有统计学意义(P﹤0.05)。结论脑电监测可以作为药物疗效监测的一项重要指标,是一种经济有效的监测方法,与临床常用美国国立卫生院神经功能评分量表比较,对患者的疗效及预后更有指导意义。
Objective To investigate the clinical value of quantitative electroencephalogram (EEG) in the treatment of severe cerebral infarction. Methods Sixty patients with first-episode severe cerebral infarction were randomly divided into two groups: group A was treated with cinepazide, group C was treated with cinepazide, and was treated with conventional therapy. Each group of patients underwent digital EEG 16-lead monopolar sampling, and the relative power values of δ and θ bands in each brain area were analyzed before and after treatment, 1 d, 3 d, 7 d, 14 d and 21 d respectively. NIHSS scores were also performed on patients at the same time. Results There was no significant difference in NIHSS scores between groups A and B at different time points before and after treatment. However, there was no significant difference in NIHSS scores between the groups A and B The relative power value was significantly lower than the control group (P <0.05). After d21, the relative power values of each frequency region in group A were significantly lower than those in group B, the difference was statistically significant (P <0.05). In group A, the relative power value of the d7 prefrontal area, ipsilateral central area, temporal area and occipital area after treatment was significantly lower than that of the control group, with significant difference between the two groups (P <0.05). Conclusion EEG monitoring can be used as an important indicator of drug efficacy monitoring. It is a cost-effective monitoring method. Compared with the commonly used NHS scores in clinical practice, EEG monitoring is more instructive for the efficacy and prognosis of patients.