论文部分内容阅读
目的探讨侧脑室增宽胎儿的染色体产前诊断和妊娠结局情况。方法选取2011年1月-2013年12月该院因胎儿侧脑室增宽进行产前诊断的107例单胎孕妇为研究组,另选取同期错过血清学筛查或因高龄进行产前诊断的50例单胎孕妇为对照组。对比分析两组产前诊断结果、妊娠结局及新生儿出生情况。结果中、重度侧脑室增宽组染色体异常的发生情况与对照组比较,差异有统计学意义(P<0.05)。非孤立性侧脑室增宽组新生儿神经系统发育异常率与对照组比较,差异有统计学意义(P<0.05)。结论中、重度胎儿侧脑室增宽与胎儿染色体核型异常存在相关性,在孕期应进行产前诊断,排除胎儿染色体异常。排除染色体异常后,非孤立性侧脑室增宽胎儿的预后明显低于正常新生儿。
Objective To investigate the chromosomal prenatal diagnosis and pregnancy outcome in patients with enlarged lateral ventricles. Methods A total of 107 singleton pregnant women with prenatal diagnosis of unilateral fetal ventricle widening from January 2011 to December 2013 were enrolled in this study. Another 50 pregnant women who missed the screening in the same period or 50 Cases of singleton pregnant women as the control group. The results of prenatal diagnosis, pregnancy outcome and newborns’ birth were compared between the two groups. Results, the occurrence of chromosomal abnormalities in patients with severe lateral ventricular enlargement compared with the control group, the difference was statistically significant (P <0.05). Compared with the control group, the rate of neonate neuronal dysplasia in non-isolated widened group of lateral ventricle was significantly different (P <0.05). Conclusions The widening of lateral ventricle in moderate and severe fetuses correlates with fetal chromosomal abnormalities. Prenatal diagnosis should be performed during pregnancy to eliminate fetal chromosomal abnormalities. After excluding chromosomal abnormalities, the prognosis of non-isolated lateral ventricles broadened significantly lower than normal newborns.