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目的:比较2型糖尿病患者(DM)、2型糖尿病伴牙周病患者(DM&AP)及牙周病患者(AP)龈沟液(GCF)中的白细胞介素-1β(IL-1β)水平,探讨DM和DM&AP糖化血红蛋白(HbA1c)浓度与IL-1β的相关性。方法:使用滤纸条法采集GCF,DM、DM&AP、AP患者及正常对照组各30例;ELISA法测定GCF中IL-1β含量;运用高效液相层析法测定DM和DM&AP的糖化血红蛋白水平。结果:DM、DM&AP、AP的GCF量和IL-1β量均高于正常对照组(P<0.05);DM&AP、AP组GCF量显著高于DM组(P<0.05);DM&AP组IL-1β含量高于DM组和AP组(P<0.05)。结论:糖尿病患者和糖尿病伴牙周病患者IL-1β均高于正常人,长期的高血糖会使糖尿病患者易患牙周病,提示糖尿病患者在关注血糖控制的同时还要高度关注牙周健康。
OBJECTIVE: To compare the levels of interleukin-1β (IL-1β) in type 2 diabetes mellitus (DM), type 2 diabetic patients with periodontal disease (DM & AP) and periodontal disease patients (GC) To investigate the correlation between DM and DM & HbA1c concentration and IL-1β. Methods: 30 cases of GCF, DM, DM & AP, AP patients and normal control group were collected by filter paper method. The content of IL-1β in GCF was determined by ELISA. The levels of HbA1c in DM and DM & AP were determined by HPLC. Results: The amounts of GCF and IL-1β in DM, DM & AP and AP were higher than those in normal control group (P <0.05). The levels of GCF in DM, AP and AP groups were significantly higher than those in DM group (P <0.05) Higher than DM group and AP group (P <0.05). Conclusion: The levels of IL-1β in patients with diabetes mellitus and diabetic with periodontal disease are higher than those in normal people. Long-term hyperglycemia may make diabetic patients susceptible to periodontal disease, suggesting that patients with diabetes pay more attention to periodontal health while paying attention to blood sugar control .