论文部分内容阅读
目的探讨动态监测血清降钙素原(PCT)在ICU老年重症肺炎患者的临床意义。方法将本院2009年3月~2013年3月70例ICU老年重症肺炎患者根据病情预后分为死亡组22例和存活组48例,使用固相夹心法酶联免疫吸附实验(ELISA)比较两组第1天、第3天、第5天、第7天的PCT浓度。结果①两组第1天、第3天PCT浓度差异无统计学意义(P>0.05),死亡组第5、7天血清PCT水平明显高于存活组,PCT水平在死亡组呈上升趋势而在存活组呈下降趋势;②死亡组第5、7天急性生理学与慢性健康状况评分Ⅱ(APACHEⅡ评分)明显高于存活组(P<0.01);③血清PCT和APACHEⅡ评分呈正相关(r=0.843,P=0.019<0.05)。结论动态监测降钙素原对老年重症肺炎患者预后评估,具有较高的应用价值。
Objective To investigate the clinical significance of dynamic monitoring of serum procalcitonin (PCT) in elderly patients with severe pneumonia in ICU. Methods Seventy patients with severe pneumonia in ICU from March 2009 to March 2013 were divided into 22 death patients and 48 survivors according to the prognosis of the disease. The patients were divided into two groups according to enzyme-linked immunosorbent assay (ELISA) Group 1, day 3, day 5, day 7 PCT concentration. Results ① There was no significant difference in PCT concentration between the first day and the third day in both groups (P> 0.05). The serum PCT levels of the 5th and 7th day after death in the death group were significantly higher than those in the surviving group, while the PCT level increased in the death group (P <0.01); ③The serum PCT and APACHEⅡ scores were positively correlated (r = 0.843, P <0.01); The serum PCT and APACHEⅡ scores were positively correlated with the scores of acute physiology and chronic health condition Ⅱ (APACHEⅡ) P = 0.019 <0.05). Conclusions The dynamic monitoring of procalcitonin in elderly patients with severe pneumonia prognosis evaluation, has a high value.