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Wagnen 等在1968年从Silymarin Mari—anum[L]Gaentn 中提取分离出这类黄酮甙类化合物,命名为水飞蓟素(silymarin 或silybun),经药理研究证明对多种肝毒
Wagnen and others in 1968 from Silymarin Mari-anum [L] Gaentn isolated flavonoid compounds such as silymarin (silymarin or silybun), pharmacological studies have shown that a variety of liver toxicity