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目的探讨骶前冲洗对直肠前切除术后局部复发的影响。方法采用Meta分析软件对1980年1月～2011年1月间发表的骶前冲洗对直肠癌前切除术局部复发影响的文献进行分析。结果共筛选出6篇文献(其中1篇文献有77名患者未确定分组,10名局部复发,67名无复发);直肠癌术后局部复发率为7.7%(367/4776),冲洗组局部复发率为6.4%(240/3732),低于未冲洗组的12.2%(127/1044),合并OR值为0.51(95%CI:0.41～0.69),差异有统计学意义(P<0.01);未确定人数并入冲洗组或未冲洗组,总局部复发率为7.8%(377/4852),冲洗组局部复发率6.6%(250/3 808)或6.4%(240/3 732),低于未冲洗组的12.2%(127/1 044)或12.3%(137/1 111),合并OR值为0.51(95%CI:0.40～0.65)或0.49(95%CI:0.39～0.62),差异有统计学意义(P<0.01)。结论骶前冲洗可降低直肠癌的局部复发率。
Objective To investigate the effect of presacral irrigation on the local recurrence after rectal resection. Methods Meta-analysis software was used to analyze the literature on the effect of pre-sacral irrigation on the local recurrence of pre-rectal cancer resected between January 1980 and January 2011. Results A total of 6 articles were screened out, of which 77 were undetermined, 10 were local recurrences, and 67 were not recurrences in one of the articles. The local recurrence rate of rectal cancer was 7.7% (367/4776) The recurrence rate was 6.4% (240/3732), lower than 12.2% (127/1044) in the unprocessed group, with a pooled OR of 0.51 (95% CI: 0.41-0.69) (377/4852). The local recurrence rate in irrigating group was 6.6% (250/3 808) or 6.4% (240/3 732), and the total number of patients in irrigating group was significantly lower than that in non-irrigating group The combined OR was 0.51 (95% CI: 0.40-0.65) or 0.49 (95% CI: 0.39-0.62) in 12.2% (127/1 044) or 12.3% (137/1 111) of the unwashed group, with a difference of There was statistical significance (P <0.01). Conclusions Presacral irrigation can reduce the local recurrence rate of rectal cancer.