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目的：评价黄芪注射液（ASG）联合1，6-二磷酸果糖（1，6-Dip）治疗小儿病毒性心肌炎（PVM）的临床疗效和对患儿细胞免疫功能的影响。方法入选我院儿科收治的PVM患儿81例，随机分为对照组44例和试验组37例。对照组给予休息、口服复合维生素和1，6-Dip 200 mg· kg-1· d-1治疗，试验组在对照组药物的基础上同时给予ASG 100 mg· kg -1，ivggt qd。治疗3周，比较2组患儿的临床疗效、不良反应及细胞免疫功能。结果试验组临床有效率（97.3％）显著高于对照组（81.8％）。2组患儿治疗后细胞免疫功能 CD3＋， CD4＋，CD8＋和NK细胞百分比较治疗前明显升高（ P＜0.05），且试验组升高更为显著（P＜0.05）。治疗后，2组患儿肌酸激酶（CK），肌酸激酶同工酶（CK-MB）和乳酸脱氢酶（ LDH）显著降低，且试验组降低更为显著（ P＜0.05）；试验组发生皮疹1例。结论 ASG联合1，6-Dip治疗PVM疗效肯定，可显著提高患儿的细胞免疫功能。“,”Objective To evaluate clinical efficacy and safety of astraga-lus combined with 1,6 -diphosphate in the treatment of pediatric viral myocarditis( PVM) and its effect on cellular immune function of pediatric patients.Methods Eighty-one children with PVM were randomly di-vided into control group ( n=44 ) and experiment group ( n=37 ).Oral mulvital and 200 mg· kg -1 · d-1 of intravenous 1,6-diphosphate were given to children in the control group as the basic treatment.And chil-dren were given 100 mg · kg -1 of astragalus plus 10% glucose 100 mL intravenous as well as the basic treatment of control group.After 3 -week treatment , the total efficacy , side effect and cellular immune func-tion of children were recorded and compared between the two groups.Results The total efficacy of experiment group ( 97.3%) was much higher than that of control group (81.8%)(P<0.05).The cellular im-mune function ( CD3 +, CD4 +, CD8 +and NK cell percentage ) was sig-nificantly improved in children compared with prior -treatment condition ( P<0.05 ) , and a much higher improvement was detected in the experi-ment group ( P<0.05 );the myocardial enzymes ( creatine kinase , crea-tine kinase isoenzyme , and lactate dehydrogenase ) were decreased after treatment, and the experiment group showed a much higher improvement. ( P<0.05 ).Only one patient had rash in the experiment group during the treatment.Conclusion Astragalus com-bined with 1,6-diphosphate has significant clinical efficacy and few side effects in children with viral myocarditis .The cellular immune function of patients can be improved by the combination regimen.