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抗菌剂402是天然大蒜素的一种类似物,是化学合成品,化学结构为乙烷硫代磺酸乙酯CH_3CH_2S(O_2)—SCH_2CH_3为一广谱抗菌剂。曾试用于菌痢。一、毒性试验402对小白鼠的急性毒性,一次口服LD50为84.2毫克/公斤,腹腔注射为26.4±4.6毫克/公斤,肌肉注射为72.4±6.2毫克/公斤。中毒死亡由于呼吸麻痹。0.1%溶液灌胃50毫升/公斤,每天一次,连续10天,对大白鼠血细胞及肝功能均无明显影响。二、刺激性口服对胃肠粘膜,注射时对局部组织,均有刺激作用,可引起急性炎症反应。低浓度(0.05%)的402溶液点眼,对家兔结膜由于化学刺激物引起炎症;高浓度时可致角膜溃疡。0.1%稀溶
Antibacterial agent 402 is an analogue of natural allicin and is a chemical synthesis product. Its chemical structure is ethyl ethanethiosulfonate CH_3CH_2S (O_2) -SCH_2CH_3 is a broad-spectrum antibacterial agent. Have tried in bacillary dysentery. Toxicity Test 402 The acute toxicity to mice was such that an oral LD50 was 84.2 mg / kg, intraperitoneal injection was 26.4 ± 4.6 mg / kg and intramuscular injection was 72.4 ± 6.2 mg / kg. Poisoned death due to respiratory paralysis. 0.1% solution gavage 50 ml / kg, once a day for 10 days, no significant effect on blood cells and liver function in rats. Second, oral stimulation of gastrointestinal mucosa, injection of local tissue, have a stimulating effect, can cause acute inflammation. Low concentration (0.05%) 402 solution eye, the rabbit conjunctiva due to chemical irritants cause inflammation; high concentrations can cause corneal ulcers. 0.1% dilute