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目的探讨抗过敏治疗对特应性儿童分泌性中耳炎(otitis media with effusion,OME)的疗效。方法选择104例OME患儿(5~14岁)为研究对象,在予以口服抗生素的基础上,随机分成SPT阳性治疗组(33例40耳,变应原皮肤点刺试验阳性)、SPT阴性治疗组(37例41耳,变应原皮肤点刺试验阴性)和对照组(34例38耳),疗程结束后随访6个月。结果治疗开始1个月后,SPT阳性治疗组总有效率为82.5%,高于SPT阴性治疗组(56.1%)及对照组(57.9%)的总有效率,且疗效经统计学分析差异有显著性。6个月后随访,SPT阳性治疗组与SPT阴性治疗组和对照组的疗效差异仍有显著性,但治疗组(SPT阳性治疗组+SPT阴性治疗组)与对照组之间疗效的差异始终无显著性。结论抗过敏治疗是针对特应性儿童OME的有效方法,变应原皮肤点刺试验可有助于抗过敏治疗的适应症选择。
Objective To investigate the effect of anti-allergy treatment on otitis media with effusion (OME) in atopic children. Methods A total of 104 OME children (aged 5-14 years) were selected as study subjects. On the basis of oral antibiotics, they were randomly divided into SPT positive group (33 cases of 40 ears, allergen skin prick test positive), SPT negative treatment (37 cases of 41 ears, allergen skin prick test negative) and the control group (34 cases of 38 ears), followed up for 6 months after the end of treatment. Results One month after the start of treatment, the total effective rate of SPT-positive group was 82.5%, higher than that of SPT-negative group (56.1%) and control group (57.9%), and the difference was statistically significant Sex. After 6 months follow-up, there was still significant difference between the SPT-positive group and the SPT-negative group and the control group, but there was no difference between the treatment group (SPT positive group + SPT negative group) and the control group Significance. Conclusion Anti-allergy treatment is an effective method for atopic children OME. The allergen skin prick test may be helpful for the indication of anti-allergy treatment.