论文部分内容阅读
目的利用核素心室显像,探讨血管紧张素II受体拮抗剂——缬沙坦对原发性高血压患者左心室功能的影响。方法本研究入选原发性高血压患者72例,随机分配(1:1)到缬沙坦(口服80～160mg/d)组或阿替洛尔(口服25～50mg/d)组,治疗8个月,治疗前后各行一次核素心室显像检查,对比分析组内治疗前后左心功能参数变化和两组间的差异。结果与治疗前比较,原发性高血压患者在缬沙坦或阿替洛尔治疗8个月后,两组收缩压与舒张压明显下降(159/101～142/89mmHg;161/103至140/90mmHg()P<0.01);左室舒张功能(以左室峰充盈率代表)明显改善(P<0.05),而在阿替洛尔治疗后8个月后左室高峰充盈率无明显的变化,两组间比较有明显的变化(P<0.05)。结论原发性高血压患者在缬沙坦治疗8个月后可使原发性高血压患者左心室舒张功能显著改善,对左心室舒张功能的作用优于阿替洛尔。
Objective To investigate the effect of valsartan, an angiotensin II receptor antagonist, on left ventricular function in patients with essential hypertension by radionuclide ventriculography. Methods A total of 72 patients with essential hypertension were randomized to receive either valsartan (80-160 mg / d orally) or atenolol (25-50 mg / d orally) for 8 Months, before and after treatment a line of radionuclide ventricular imaging examination, comparative analysis of intra-group before and after treatment of left ventricular function parameters and differences between the two groups. Results Compared with those before treatment, systolic and diastolic blood pressures decreased significantly in patients with essential hypertension after valsartan or atenolol treatment for 8 months (159/101 ~ 142 / 89mmHg; 161/103 to 140 /90mmHg()P<0.01); left ventricular diastolic function (represented by left ventricular peak filling rate) was significantly improved (P <0.05), while there was no significant difference in left ventricular peak after 8 months of atenolol treatment Changes, there was a significant change between the two groups (P <0.05). Conclusion In patients with essential hypertension, the left ventricular diastolic function was significantly improved in patients with essential hypertension after 8 months of treatment with valsartan, and the effect on left ventricular diastolic function was superior to atenolol.