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测定了未孕妇女、正常孕妇和妊高征患者的血胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白—胆固醇(HDL-C)及亚组(HDL_3-C、HDL_2-C),低密度脂蛋白—胆固醇(LDL-C)、超氧化物歧化酶(SOD)、丙二醛(MDA)和维生素 E(VE)的水平。结果显示:孕妇血中各项血脂均明显高于未孕妇女(P<0.01),妊高征组与正常孕妇组相比,TC、TG 更高(P<0.01),HDL-C 有下降趋势,HDL_3-C 明显下降(P<0.01),而 LDL-C 则明显升高(P<0.05)。正常孕妇与未孕妇女相比,SOD 下降,MDA 升高(P<0.01),但 VE 明显升高(P<0.01),提示抗氧化能力增强。而妊高征与正常孕妇相比,MDA 升高,SOD 和 VE 下降更明显(P<0.05～0.01)。而且 SOD 与 MDA、MDA 与 VE 呈显著负相关(P<0.05～0.01)。表明脂质过氧化作用的增强和抗氧化能力下降。此外,高原低氧环境对 SOD、MDA 的影响亦有可能参与了妊高征的形成。
(TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C) and subgroups (HDL-3-C, HDL-C) of non-pregnant women, normal pregnant women and pregnancy- (LDL-C), superoxide dismutase (SOD), malondialdehyde (MDA) and vitamin E (VE) were detected by ELISA. The results showed that all the blood lipids in pregnant women were significantly higher than those in non-pregnant women (P <0.01). Compared with normal pregnant women, the serum levels of TC and TG were higher (P <0.01) and HDL-C decreased , HDL_3-C decreased significantly (P <0.01), while LDL-C increased significantly (P <0.05). Normal pregnant women compared with non-pregnant women, decreased SOD, MDA increased (P <0.01), but VE was significantly higher (P <0.01), suggesting that increased antioxidant capacity. Compared with normal pregnant women with PIH, MDA increased, and SOD and VE decreased more significantly (P <0.05 ~ 0.01). There was a significant negative correlation between SOD and MDA, MDA and VE (P <0.05 ~ 0.01). This shows that the lipid peroxidation and antioxidant capacity decreased. In addition, the plateau hypoxic environment on the impact of SOD, MDA may also be involved in the formation of pregnancy-induced hypertension.