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目的 :研究丹参、钙剂联合用药预防妊高征的发生。方法 :应用 MP妊高征监测系统对 76 4例 2 0～ 2 8孕周妇女进行预测妊高征 ,筛选出妊高征高危人群 84例 ,随机分为预防组 42例 ,口服复方丹参 4片 ,每日二次 ,钙尔奇— D12 0 0 mg,每日一次至分娩。安慰组 42例 ,口服维生素 C10 0 m g,每日三次至分娩。观察两组妊高征的发生率、服药前后血液动力学变化、分娩情况和新生儿情况。结论 :预防组妊高征 3例 ,发生率为 7.14% ,无重度 ;安慰组发生 12例 ,发生率为 2 8.5 7%。其中轻度 7例 ,重度 2例 ,两组有显著性差异 (P<0 .0 0 1)。两组服药前后血流动力学指标预防组无明显变化 ,安慰组变化显著 (P<0 .0 1)。预防组新生儿体重 336 7± 32 8.6克 ,安慰组新生儿体重 30 5 7± 2 37.2克 ,两组相比差异显著 (P<0 .0 5 )。结论 :对妊高征高危人群进行预防性补钙及口服丹参能有效降低妊高征的发生 ,提高孕产妇及新生儿的健康状况
Objective: To study the prevention of pregnancy-induced hypertension syndrome by combination of Salvia miltiorrhiza and calcium. Methods: A total of 76 4 pregnant women with gestational age from 20 to 28 were enrolled in this study. Eighty-four pregnant women with high risk of PIH were selected and randomly divided into prevention group (n = 42) and oral administration of salvia miltiorrhiza , Twice daily, Calcium - D12 0 0 mg, once daily to deliveries. Forty-two patients in the placebo group received orally 10 mg vitamin C three times a day until delivery. The incidence of PIH, the changes of hemodynamics before and after taking the medication, the situation of delivery and the newborn were observed. Conclusion: PIH in prevention group was 3 cases, the incidence was 7.14%, no severe; 12 cases in comfort group, the incidence was 2 8.57%. There were 7 mild cases and 2 severe cases with significant difference (P <0. 001). There was no significant change in hemodynamics prophylaxis group before and after treatment in the two groups, the comfort group changed significantly (P <0.01). The weight of newborns in prevention group was 336 ± 32.66 g and that in comfort group was 30 57 ± 2 37.2 g, there was significant difference between the two groups (P <0.05). Conclusion: Preventive calcium supplement and oral administration of Salvia miltiorrhiza can effectively reduce the incidence of pregnancy-induced hypertension and improve the health status of pregnant women and newborns