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目的加强对有突出肾损害的原发性淀粉样变性的认识，提高诊断水平。方法对15例有突出肾损害的原发性淀粉样变性病例资料从多脏器受累情况、骨髓穿刺及活检、血／尿蛋白电泳和免疫电泳及治疗预后等方面进行总结和分析。结果肾脏、消化、循环和血液系统有不同程度受累，部分病例有骨髓浆细胞增生，血／尿中检出单克隆蛋白。结论本病肾损害有一定特点，尤其特异性的肾脏病理改变可明确诊断。
Objective To strengthen awareness of primary amyloidosis with prominent renal impairment and improve the diagnostic level. Methods The data of 15 patients with primary amyloidosis with renal damage were summarized and analyzed from multiple organ involvement, bone marrow aspiration and biopsy, blood / urine protein electrophoresis, immunoelectrophoresis and prognosis. Results The kidneys, digestive, circulatory and hematological systems were affected to varying degrees. In some cases, there was bone marrow plasma cell proliferation and monoclonal / protein detection in blood / urine. Conclusion The disease has some characteristics of renal damage, especially specific renal pathological changes can be a clear diagnosis.