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目的：研究不同人群中红细胞ＣＲ１基因组密度多型性与红细胞免疫粘附肿瘤细胞能力的相关性。方法：采用ＰＣＲ加ＨｉｎｄⅢ酶切技术测定红细胞ＣＲ１基因组密度多型性（ＨＨ型、ＨＬ型、ＬＬ型），采用肿瘤红细胞花环试验测定红细胞免疫粘附肿瘤细胞的能力。结果：在不同人群中，ＨＨ型红细胞免疫粘附肿瘤细胞的能力明显大于ＨＬ型红细胞，而ＨＬ型红细胞免疫粘附肿瘤细胞的能力明显大于ＬＬ型红细胞。结论：红细胞免疫粘附肿瘤细胞的能力与ＣＲ１基因组密度多型性有关。
OBJECTIVE: To investigate the correlation between erythrocyte CR1 genomic polymorphism and erythrocyte immune adherent tumor cell abilities in different populations. METHODS: The red blood cell CR1 genome density polymorphisms (HH type, HL type, and LL type) were determined by PCR and HindIII digestion, and red blood cell rosette assay was used to determine the ability of red blood cells to adhere to tumor cells. RESULTS: In different populations, the ability of HH-type red blood cells to adhere to tumor cells was significantly greater than that of HL-type red blood cells, whereas the ability of HL-type red blood cells to adhere to tumor cells was significantly greater than that of LL-type red blood cells. Conclusion: The ability of red blood cells to adhere to tumor cells is related to the polymorphism of CR1 genome.