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核转录因子-κB(NF-κB)是研究最为广泛的转录因子之一,在机体的免疫应答、炎症反应和细胞的生长、发育等方面发挥重要作用。血管病变广义上可认为是一种炎症反应,涉及血管内皮损伤、内膜增生及由此引起的血管狭窄、新生血管的生成等,我们认为NF-κB在以上各血管病变中均通过不同机制,直接或间接发挥着重要的作用。同时,以NF-κB作为靶点治疗各种疾病,日益受到学者们的关注。
Nuclear factor-kappa B (NF-κB) is one of the most widely studied transcription factors and plays an important role in the body’s immune response, inflammatory response and cell growth and development. Vascular lesions in a broad sense can be considered as an inflammatory reaction, involving vascular endothelial injury, intimal hyperplasia and the resulting vascular stenosis, angiogenesis, etc., we believe that NF-κB in the above vascular lesions are through different mechanisms, Directly or indirectly play an important role. At the same time, the treatment of various diseases with NF-κB as a target has attracted more and more scholars’ attention.