Understanding self-accelerated water diffusion within poly-lactic acid via molecular dynamics simula

• 作 者: Xiaohui Wang Jiachen Li Li Zha
• 机 构: SchoolofEconomicsandManagement,DepartmentofChemistry
• 出 处: 中国化学工程学报:英文版
• 发表日期: 2019年4期
• 关键词: Water DIFFUSION COEFFICIENT CONTROLLED release Molecular dynamic simulation
• 基金项目: the Scientific Developing Foundation of Tianjin Municipal Education Commission(2017SK055),the Project Grants 521 Talents Cultivation of Zhejiang Sci-Tech University.

Poly-lactic acid(PLA) is widely used as a controlled drug release material and the diffusion property of water within the polymer matrix is closely related to the drug release profile. This paper studies the water diffusion in PLA by molecular dynamic sim