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Angew.Chem.Int.Ed.2015,54,4661~4664手性含硅化合物不仅在有机合成化学有重要的研究价值,而且在药物化学中也有重要的应用价值.通过对烯烃的不对称硅氢化反应可以直接制备该类化合物,但由于较难识别潜手性底物的选择性,对于简单1,1-二取代烯烃的高对映选择性硅氢化反应很难实现.浙江大学化学系陆展特聘研究员利用手性廉价金属铁催化剂,成功实现1,1-二取代烯烃和二苯基硅氢的不对称硅氢化反应,高产率、高选择性地得到反马氏加成的手性硅化合物.原料简单
Angew.Chem.Int.Ed.2015,54,4661 ~ 4664 The chiral silicon compounds not only have important research value in the field of organic synthesis chemistry, but also have important application value in the pharmaceutical chemistry.Asymmetric hydrosilylation of olefins The reaction can be directly prepared for these compounds, but due to the more difficult to identify the selectivity of the underlying substrate, for the simple 1,1-disubstituted olefin high enantioselective hydrosilation reaction is difficult to achieve. Lu Department of Chemical Engineering, Zhejiang University Distinguished researchers using the chiral cheap metal iron catalyst, the successful realization of 1,1-disubstituted olefin and diphenylsilyl hydrogen asymmetric hydrosilation reaction, with high yield, high selectivity to the anti-Markov additive chiral silicon compounds The raw material is simple