论文部分内容阅读
慢性心力衰竭是心内科治疗学上的难题,具有较高患病率和病死率。流行病学资料显示:全球心力衰竭患病人数高达2250万,每年新增病例数200万。我国2003年一项心力衰竭流行病学调查资料显示。我国35～74岁人群中约有心力衰竭患者400万人。中、重度心力衰竭的5年病死率可达3096～50%。与此同时,因心力衰竭引发的医疗花费相当巨大。因此,近年来对心力衰竭的治疗进行了大量研究,取得了很大进展,研究显示心脏矢同步的心力衰竭患者常规药物治疗效果往往欠佳。目前应用心脏再同步化治疗(CRT),不仅能缓解患者临床症状,而且使心衰患者住院率、死亡率明显下降。一、心力衰竭的病理生理:心力衰竭患者往往合并传导异常,导致房室、室间和/或室内运动不同步。房室不同步常表现为 PR 间期延长,左心房收缩相对提前到心室快速充盈期,使左心室充盈减少。
Chronic heart failure is a difficult problem in cardiology, with a high prevalence and mortality. Epidemiological data show that: the global heart failure patients up to 22.5 million, an annual increase of 2 million cases. China 2003 epidemiological survey of heart failure data. About 35 million people in our country aged 35-74 are suffering from heart failure. In 5 years, severe heart failure mortality up to 3096 ~ 50%. In the meantime, medical costs due to heart failure are substantial. Therefore, a great deal of research has been done on the treatment of heart failure in recent years, and great progress has been made. Studies have shown that conventional medical treatment of heart failure patients with heart-synchronous heart failure often fails. The current application of cardiac resynchronization therapy (CRT), not only can alleviate the clinical symptoms, but also make hospitalization rate of heart failure, mortality decreased significantly. First, the pathophysiology of heart failure: Heart failure patients often combined conduction abnormalities, resulting in atrioventricular, ventricular and / or ventricular out of synchronization. Atrioventricular often show PR interval prolongation, left atrial contraction relative to the rapid ventricular filling phase, so that the left ventricular filling decreased.