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目的血清IL-6、IL-8、IL-10、TNF-α的检测对儿童肺炎支原体肺炎(MPP)诊断的临床价值分析。方法以核工业四一七医院2015年3月至2016年3月收治的1~12岁MPP病例为研究对象,同时选取年龄和性别构成一致的健康儿童作为对照,对不同分期的MPP病例和健康对照组儿童的血清IL-6、IL-8、IL-10、TNF-α水平进行分析,Pearson相关分析用于急性期MPP病例血清IL-6、IL-8、IL-10、TNF-α水平的相关性分析。结果共纳入MPP儿童病例90例,平均年龄为(6.13±1.49)岁,病例中急性期和恢复期病例各45例。健康对照组儿童40人,平均年龄为(6.05±2.15)岁。急性期MPP组的血清IL-6、IL-8、IL-10、TNF-α水平均高于恢复期MPP组和健康对照组(均P<0.01)。肺部纤维化急性期MPP病例血清IL-6、IL-8、IL-10、TNF-α水平均高于未发生纤维化者,差异具有统计学意义(均P<0.01)。急性期MPP病例血清IL-6与IL-8、IL-10、TNF-α、血清IL-8与IL-10、TNF-α、血清IL-10与TNF-α均呈正相关关系(r=0.243~0.455,均P<0.05)。结论急性期MPP病例的血清IL-6、IL-8、IL-10、TNF-α异常升高,其在患者发病过程中起重要的作用,并且与患者肺纤维化有关。
Objective To investigate the clinical value of serum IL-6, IL-8, IL-10 and TNF-α in the diagnosis of children’s Mycoplasma pneumoniae pneumonia (MPP). Methods The MPP patients aged from 1 to 12 years who were treated in Nuclear Industry Hospital of Shandong Children’s Hospital from March 2015 to March 2016 were selected as research objects. At the same time, healthy children of the same age and sex were selected as control group. The levels of IL-6, IL-8, IL-10 and TNF-α in the control group were analyzed. Pearson correlation analysis was used to detect the levels of IL-6, IL-8, IL-10 and TNF- Correlation analysis. Results A total of 90 children with MPP were enrolled in this study. The average age was (6.13 ± 1.49) years old. The number of acute and convalescent cases was 45 in each case. The healthy control group of 40 children, the average age was (6.05 ± 2.15) years old. The levels of IL-6, IL-8, IL-10 and TNF-α in acute MPP group were higher than those in MPP recovery group and healthy control group (all P <0.01). The levels of IL-6, IL-8, IL-10 and TNF-α in MPP patients with acute pulmonary fibrosis were significantly higher than those without fibrosis (all P <0.01). The levels of IL-6, IL-10, TNF-α, IL-8 and IL-10, TNF-α, IL-10 and TNF-α in acute MPP patients were positively correlated (r = 0.243 ~ 0.455, all P <0.05). Conclusions The serum levels of IL-6, IL-8, IL-10 and TNF-α in patients with acute MPP are abnormally elevated, which play an important role in the pathogenesis of patients with pulmonary fibrosis.