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众所周知,血管紧张素Ⅱ,K~+和促肾上腺皮质激素(ACTH)能够刺激醛固酮分泌,但已知的刺激因子并不能园满解释各种情况下对醛固酮的调节。早先有报告说,非ACTH垂体因子可能在调节醛固酮分泌中起作用。1965年,以羊脑垂体腺中成功地提取出β-促脂素(β-LPH)。ACTH和β-促脂激素在脑垂体腺中具有共同的前体分子。近来,β-LPH作为鸦片样肽激素前体引起人们的极大兴趣,但尚缺乏β-LPH对肾上
It is well known that angiotensin II, K ~ + and adrenocorticotropic hormone (ACTH) stimulate aldosterone secretion, but known stimuli do not adequately explain the aldosterone modulation in various contexts. Earlier reports suggest that non-ACTH pituitary factors may play a role in the regulation of aldosterone secretion. In 1965, β-lipolipid (β-LPH) was successfully extracted from the sheep pituitary gland. ACTH and beta-lipotropin have common precursor molecules in the pituitary gland. Recently, β-LPH has been of great interest as an opioid peptide hormone precursor, but the lack of β-LPH on the kidneys