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目的观察急性冠状动脉综合征介入术前应用他汀类药物强化治疗对心肌损伤的保护作用。方法 80例不稳定型心绞痛患者随机分为强化治疗组和对照组,每组各40例,强化治疗组在介入术前给予3～7d阿托伐他汀口服,40mg/d,对照组在介入术前不使用他汀类药物。2组其他常规治疗均相同。比较2组患者PCI术后心肌损伤标记物和血脂水平的变化情况。结果强化治疗组和对照组术后CRP水平均明显增加,但是治疗组在术后3d和术后1周时出血中CRP水平迅速下降,与对照组比较差异有统计学意义(P<0.05)。2组患者治疗后的血脂水平较治疗前下降不明显,差异均无统计学意义(P>0.05)。结论急性冠状动脉综合征介入术前应用他汀类药物强化治疗具有降低PCI术后炎症反应的可能,从而减少心血管事件的发生。
Objective To observe the protective effect of statin therapy on myocardial injury in patients with acute coronary syndrome before intervention. Methods Eighty patients with unstable angina pectoris were randomly divided into intensive treatment group and control group, 40 cases in each group. The intensive treatment group received oral atorvastatin 3 ~ 7 days 40mg / d before intervention, Do not use statins before. The other 2 groups of other conventional treatment are the same. The changes of myocardial injury markers and blood lipid levels after PCI were compared between the two groups. Results The postoperative CRP levels in the intensive treatment group and the control group were significantly increased. However, the CRP level in the treated group decreased rapidly at 3 days and 1 week after operation, which was significantly different from the control group (P <0.05). The level of blood lipids in two groups after treatment was not significantly lower than that before treatment, and the difference was not statistically significant (P> 0.05). Conclusions The pretreatment of acute coronary syndrome with statin therapy can reduce the possibility of inflammatory reaction after PCI and reduce the incidence of cardiovascular events.