四川多发性硬化发病因素的初步探讨

• 作 者: 徐文桢 苟婴如 裴冀 东云华 高国勋 王代德 蔡凤全
• 机 构: 华西医大神经科,华西医大神经科,中国医学科学院输血研究所,华西医大公共卫生学院临床检验教研组,四川省人民医院神经科,成都空军医院,成都363医院,
• 出 处: 华西医讯
• 发表日期: 1987年01期
• 关键词: 多发性硬化 麻疹抗体 寡克隆 免疫球蛋白 组织相容性抗原 免疫反应异常 滴度 抗原频率 IgG 脑脊液检查

本文分析了 MS 患者的 HLA 定型、脑脊液免疫学改变、血和脑脊液麻疹抗体滴度等项指标,提示四川地区发生的 MS 存在有遗传背景,对麻疹病毒感染免疫反应增强及在中枢神经系统内有免疫反应异常现象;表现患者与 HLA-B_(16)、B_(36)、B_(39)、Bw_(54)、Dw_9等抗原有显著关联。血清麻疹抗体水平增高、但 CNS 内不增高。CSF 的 IgG 相对值增加和寡克隆区带阳性,对这三方面改变的因果关系和相互作用还有待研究。可认为,在中国 MS 的发病机理亦与多因素有关。

This article analyzes the MS patients HLA typing, immunological changes in cerebrospinal fluid, blood and cerebrospinal fluid antibody titer and other indicators, suggesting that there is a genetic background in MS in Sichuan Province, the immune response to measles virus infection and in the central nervous system Immune reaction abnormalities; the performance of patients with HLA-B_ (16), B_ (36), B_ (39), Bw_ (54), Dw_9 and other antigens were significantly associated. Serum measles antibody levels increased, but not increased within the CNS. CSF IgG relative increase in value and oligoclonal band positive, the changes in these three aspects of the causal relationship and interaction remains to be studied. It can be considered that the pathogenesis of MS in China is also related to many factors.