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哺乳动物的生殖活动受神经系统,特别是下丘脑促性腺区的控制。免疫组织化学的研究已经证明啮齿类动物的下丘脑内侧视前区(mPOA)及下丘脑前区(AHA)中有含促性腺激素释放激素(GnRH)的神经细胞体存在。Dyer等发现mPOA-AHA神经元的电活动随生殖周期而发生变化。Wuttke还观察到,宫颈刺激能使mPOA中神经元的放电与血浆LH的浓度发生一致性变化。近年来,许多学者注意到去甲肾上腺素(NE)在LH分泌的调有中有重要的作用。但是,关于NE对与生殖有关的神经元活动的直接影响,目前报导仍较少。本实验的目的是探讨mPOA-AHA中与生殖有关的神经元的活动规律以及脑室注射NE对这些神经元活动的影响。
Mammalian reproductive activities are controlled by the nervous system, especially the hypothalamic gonadal zone. Immunohistochemical studies have shown that rodent hypothalamic medial preoptic area (mPOA) and hypothalamic precordial (AHA) neurons present with gonadotropin-releasing hormone (GnRH) -derived neuronal bodies. Dyer et al found that the electrical activity of mPOA-AHA neurons changes with the reproductive cycle. Wuttke also observed that cervical stimulation consistently changes the firing of neurons in mPOA to the concentration of plasma LH. In recent years, many scholars have noticed that norepinephrine (NE) plays an important role in the modulation of LH secretion. However, there are still few reports on the direct impact of NE on reproductive-related neuronal activity. The purpose of this experiment was to investigate the activity of reproductive-related neurons in mPOA-AHA and the effect of intracerebroventricular injection of NE on these neuronal activities.