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目的:评价经颅多普勒(TCD)检测脑动静脉间脉搏波传导时间(CAV-PWT)的临床价值。方法:选择86例接受TCD检测及数字化减影血管造影术(DSA)检查的缺血性脑血管病患者,直线相关方法分析CAVPWT与颅内动脉狭窄程度的相关性。随访半年,记录脑卒中例数,应用Logistic回归分析评估CAV-PWT与脑卒中的危险程度。结果:DSA与TCD检测颈内动脉系统及椎-基底动脉系统狭窄率差异均无显著性,分别为52.33%vs 47.86%(P=0.056)、61.63%vs 56.98%(P=0.059)。CAV-PWT及平均动脉压与颅内动脉狭窄率呈正相关(r=0.832,P=0.025;r=0.625,P=0.040)。多元Logistic回归分析显示CAV-PWT是脑卒中的独立预测因子(OR=1.527)。结论:TCD检测CAV-PWT能有效评估颅内动脉狭窄程度,对预后具有临床价值。
Objective: To evaluate the clinical value of transcranial Doppler (TCD) in detecting cerebral artery and vein pulse wave duration (CAV-PWT). Methods: Totally 86 patients with ischemic cerebrovascular disease undergoing TCD examination and digital subtraction angiography (DSA) were enrolled. The correlation between CAVPWT and intracranial arterial stenosis was analyzed by linear correlation method. Followed up for six months, recorded the number of stroke cases, the use of Logistic regression analysis to assess the risk of CAV-PWT and stroke. Results: There was no significant difference between DSA and TCD in the detection of stenosis rate of internal carotid artery and vertebrobasilar artery, which were 52.33% vs 47.86% (P = 0.056), 61.63% vs 56.98% (P = 0.059) respectively. CAV-PWT and mean arterial pressure were positively correlated with intracranial arterial stenosis (r = 0.832, P = 0.025; r = 0.625, P = 0.040). Multiple logistic regression analysis showed that CAV-PWT was an independent predictor of stroke (OR = 1.527). Conclusion: TCD detection of CAV-PWT can effectively assess the degree of intracranial artery stenosis, and has clinical value of prognosis.