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20例口腔鳞癌做电镜检直。浸润间质散在的癌细胞常无基底膜形成,桥粒减少。在癌巢周边者多有基底膜形成,但多处见伪足状突起突破基底膜,有时见多层基底膜或基底膜样物质沉着。癌巢中常见不全角化珠形成,有分化潜能的肿瘤细胞能模拟人正常口腔粘膜无角化上皮的分化过程,出现单根网状张力细丝,致密核心型膜被颗粒以及椭圆形高密度透明角质蛋白颗粒,这种分化多不完全和紊乱。有的癌细胞含多种类型膜被颗粒一包括中间型者。角化倾向的癌细胞核内见多种类型核小体,本文简单地讨论了核小体与单纯癌疹病毒感染及其和鳞癌发生的关系。
Twenty cases of oral squamous cell carcinoma were examined by electron microscopy. Infiltrating interstitial scattered cancer cells often have no basement membrane formation and reduced desmosomes. Substantial basement membranes form in the periphery of cancer nests, but multiple pseudopodia strike through the basement membrane, sometimes with multiple basement membranes or basement membrane-like material. The formation of incompletely keratinized beads in cancerous nests. Differentiating tumor cells can mimic the differentiation process of human normal oral mucosal keratinized epithelium. Single reticular tension filaments appear, and dense core membranes are granules and oval high density. Transparent keratin protein particles, such differentiation is incomplete and disordered. Some cancer cells contain multiple types of membrane granules, including intermediate types. Many types of nucleosomes are seen in the keratinizing cancer cell nucleus. This article briefly discusses the relationship between nucleosome and cancer-specific herpes simplex virus infection and the occurrence of squamous cell carcinoma.