论文部分内容阅读
采用免疫组织化学技术检测了22例晚期血吸虫病（下称晚血）患者肝内T细胞亚群。发现晚血患者肝内T细胞可集中分布于虫卵肉芽肿外层或者散在分布于非肉芽肿部位的虫卵附近，广泛纤维化的区域无T细胞浸润。肉芽肿和非肉芽肿部位的T细胞均以CD8+T细胞（抑制性／细胞毒T细胞）为主。晚血患者肝脏病变以汇管区纤维化为主，浸润细胞不多，仅27．27％（6／22）患者肝内存在已被免疫调节了的慢性虫卵肉芽肿。提示晚血患者肝内细胞免疫反应很弱，肝内的CD+8T细胞可能主要是抑制性T细胞（Ts）。
Immunohistochemical techniques were used to detect intrahepatic T cell subsets in 22 patients with advanced schistosomiasis (hereinafter referred to as late blood). Found that patients with liver blood T cells within the liver can be concentrated in the outer layer of egg granuloma or scattered in the non-granuloma area near the eggs, extensive fibrosis area without T cell infiltration. T cells from granulomatous and non-granulomatous sites were predominantly CD8 + T cells (inhibitory / cytotoxic T cells). Liver disease in patients with late blood to portal fibrosis, infiltrating cells is small, only 27.27% (6/22) of patients with immunocompromised chronic intranuclear egg granuloma. It is suggested that intrahepatic cellular immune response is weak in patients with late blood and CD + 8 T cells in liver may be mainly suppressor T cells (Ts).