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目的考察丹参酮ⅡA磺酸钠(STS)注射剂与10种不同药物配伍后在0.9%氯化钠注射剂中的稳定性。方法室温下,将STS分别与10种药物配伍,考察配伍液在0~24 h内外观、pH值、含量的变化情况。结果 10种配伍液的外观在24h内除青霉素钠注射剂和银杏达莫注射剂由橘红色变橘黄色之外,其他配伍液外观颜色无变化。STS注射剂与银杏达莫注射剂、多巴胺注射剂、马来酸桂哌奇特注射剂、硝酸甘油注射剂和奥拉西坦注射剂配伍后pH值和含量都无明显变化,但与其余5种药物配伍后pH值或含量均发生了变化。结论 STS注射剂与多巴胺注射剂、马来酸桂哌奇特注射剂、硝酸甘油注射剂和奥拉西坦注射剂配伍外观、pH值、含量均稳定,其余6种药物不宜配伍。
Objective To investigate the stability of sodium tanshinone Ⅱ A sulfonate (STS) injection in 0.9% sodium chloride injection after compatibility with 10 different drugs. Methods The compatibility of STS with 10 drugs was investigated at room temperature. The changes of appearance, pH value and content of compatibility solution within 0-24 h were investigated. Results The appearance of 10 kinds of compatibility liquid showed no change in the appearance color of the other compatibility solutions except that sodium penicillin injection and gingko damo injection were changed from orange to orange in 24h. STS injection and gingko Damo injection, dopamine injection, cinepazide maleate injection, nitroglycerin injection and oxiracetam injection compatibility and pH values were no significant changes, but with the remaining five kinds of drugs compatibility or pH or The content has changed. Conclusions STS injection and dopamine injection, cinepazide maleate injection, nitroglycerin injection and oxiracetam injection compatibility, pH, content were stable, the other six drugs should not be compatible.