1型糖尿病患者胎儿胎盘循环中K_(ATP)通道功能受损

• 作 者: Bisseling T.M. Versteegen M.G. Van Der Wal S. 王远菊
• 机 构: Dept. of Pharmacology- Toxicology University Medical Center Nijmejen Netherland Dr,
• 出 处: 世界核心医学期刊文摘(妇产科学分册)
• 发表日期: 2005年07期
• 关键词: 胎儿胎盘循环 通道功能 糖尿病 糖尿病组 优降糖 胎盘 胎儿胎盘 钾离子通道功能 体外分离 钾离子通道

Objective: The increased perinatal morbidity in diabetes may be partly related to vascular dysfunction. Because potassium channels play an important role in the regulation of vascular tone, this study explores the impact of diabetes on potassium channel function in the fetoplacental vascular bed. Study design: Vascular potassium channel function was investigated by ex vivo dual perfusion of isolated placental cotyledons (n = 47). Appropriate control experiments were carried out to exclude nonspecific effects. Results: Glibenclamide (KATP channel blocker) increased perfusion pressure to a maximum fetoplacental arterial pressure of 37 ± .6 mm Hg in controls versus 15 ± 6 mm Hg in diabetes (P <. 05). 4- Aminopyridine (KV channel blocker) equally increased fetoplacental arterial pressure in controls, and in diabetes (21 ± 4 mm Hg vs 22 ± 2 mm Hg). Apamin and charybdotoxin (KCa channel blockers) caused a negligible rise in fetoplacental arterial pressure. Conclusion: In the fetoplacental circulation, KATP channels and KV channels significantly contribute to baseline vascular tone. In diabetes, vascular KATP channel function is impaired.

Objective: The increased perinatal morbidity in diabetes may be partly related to vascular dysfunction. The study also explored the impact of diabetes on potassium channel function in the fetoplacental vascular bed. Vascular potassium channel function was investigated by ex vivo dual perfusion of isolated placental cotyledons (n ​​= 47). Appropriate control experiments were carried out to exclude nonspecific effects. Results: Glibenclamide (KATP channel blocker) increased perfusion pressure to a maximum fetoplacental arterial pressure of 37 ± .6 mm Hg in controls versus 15 ± 6 mm Hg in diabetes (P <. 05). 4-Aminopyridine (KV channel blocker) equally increased fetoplacental arterial pressure in controls, and in diabetes (21 ± 4 mm Hg vs 22 ± 2 mm Hg). Apamin and charybdotoxin (KCa channel blockers) caused a negligible rise in fetoplacental arterial pressure. Conclusion: In the fetoplacenta L, KATP channels and KV channels significantly contribute to baseline vascular tone. In diabetes, vascular KATP channel function is impaired.