Detection of thiopurine s-methyltransferase mutations by template directed determinator in incorpora

• 作 者: 白玉杰 赵锦荣 张文红 薛丽 郭晏海 闫小君
• 机 构: InstituteofGeneDiagnosticTechnology
• 出 处: 中国人民解放军军医大学学报：英文版
• 发表日期: 2003年6期
• 关键词: s-转甲基酶 模板定量化学测定仪 TDI-FP TPMT基因 基因转换 thiopurine S-methyltransferase (TPMT) templ
• 基金项目: Shannxi Science & Technology Foundation

Objective:To develop a new method for the detection of TPMT gene mutations and determine thefrequencies of four TPM alleles,TPMT*1,*3A,*3B and *3C in a healthy Chinese population.Methods:A TDI-FP assay system was set up in out lab.To evaluate this system,