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自1963年Bcrson等引进甲状旁腺激素(PTH)的放射免疫测定法后,由于一些实验室报告了差异甚大的结果,其临床应用受到影响.正常人与甲状旁腺机能亢进患者之间的血清免疫反应性PTH(iPTH)水平的重叠范围为0-50%.此外,Reiss等报告,甲状旁腺腺瘤患者的血清iPTH水平不因钙输注而降低.而Potts及其同工发现,在类似病例组,对诱发的高钙血症的反应为,血清iRTH水平显著降低.不同研究者所测PTH结果的矛盾,直到Berson等发现循环血液中PTH的存在不止一种形式时,才有了清楚地解释.此后,一些实验室试图解释多种循环形式iPTH的临床和生理学的重要性.现已明确,循环iPTH是完整激素(分子量9500)和低分子量的激素片段(PTH分子的羧基末端和氨基末端
Since 1963, Bcrson and other introduction of parathyroid hormone (PTH) after radioimmunoassay, as some laboratories reported a very different results, its clinical application is affected.Normal individuals and patients with hyperparathyroidism serum In addition, Reiss et al reported that serum iPTH levels in patients with parathyroid adenomas did not decrease due to calcium infusion, while Potts and colleagues found that in patients with In a similar case-group, the response to induced hypercalcaemia was a significant reduction in serum iRTH levels, and conflicting PTH results measured by different investigators did not exist until Berson et al. Found more than one form of circulating PTH in circulation Since then, several laboratories have attempted to explain the clinical and physiological importance of various circulating forms of iPTH.It has now been clear that circulating iPTH is a hormone of intact hormone (molecular weight 9500) and low molecular weight hormone fragments (carboxyl terminal of PTH molecule and Amino terminus