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目的:观察中药脑肺康对实验性犬心力衰竭的保护作用.方法:麻醉犬静注戍巴比妥钠、诱发急性心力衰竭.测定心输出量(CO)、左室压(LVP)、左室末期舒张压(LVEDP)、测量±dp/dtmax记录Ⅱ导心电图(ECG)、以上指标同步记录于RM-6000多导生理记录仪上.记录心衰前基础值,然后用恒流泵输入2%戍巴比妥钠(0.2ml·kg~(-1)·min~(-1))在dp/dt (?)下降约75%时改为0.08ml·kg~(-1)·min~(-1),保持10分钟,记录各项指标,作为造型后给药前的心衰值.随后由十二指肠推入通脉康,记录给药后15,30,45,60,90,120,180分钟的各项指标.
OBJECTIVE: To observe the protective effect of Chinese medicine Naofeikang on experimental canine heart failure. Methods: Anesthetize dogs with intravenous injection of pentobarbital and induce acute heart failure. Determine cardiac output (CO), left ventricular pressure (LVP), left End-systolic diastolic pressure (LVEDP), measurement of ±dp/dtmax recording II lead electrocardiogram (ECG), the above indicators were recorded on the RM-6000 multi-channel physiological recording instrument. Record the pre-failure baseline value, and then enter the constant flow pump 2 % barbiturate sodium (0.2 ml·kg -1 ·min -1) was changed to 0.08 ml·kg -1 min -1 when dp/dt (?) decreased by approximately 75% (-1), Hold for 10 minutes, record each index as a heart failure value before modeling, and then push the duodenum into Tongmaikang, record 15, 30, 45, 60, 90, 120, 180 after administration. Minutes of indicators.