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胰腺炎合并 Crohn 病往往由硫唑嘌呤、皮质类固醇或柳氮磺胺吡啶引起。柳氮磺胺吡啶或磺胺吡啶是与5-对氨水杨酸(5-ASA)结合。柳氮磺胺吡啶由于其血中浓度高及其结构与噻嗪类相似而发生副作用。1988～1989年先后有报告4例急性胰腺炎,分别由水杨酰水杨酸偶氮二钠、灭滴灵及柳氮磺胺吡啶引起。本文报道1例由5-ASA(mesalazine)引起。病例患者男性,34岁。因下腹痛、腹泻及体重下降而入院。结肠镜及活检组织学证实为 Crohn 病。患者无上腹痛,体检无异常发现,给予 mesalazine
Pancreatitis with Crohn’s disease is often caused by azathioprine, corticosteroids, or sulfasalazine. Sulfasalazine or sulfapyridine is bound to 5-p-aminosalicylic acid (5-ASA). Sulfasalazine produces side effects due to its high blood concentration and its structure similar to that of thiazides. From 1988 to 1989, 4 cases of acute pancreatitis were reported, which were caused by salicylate, disodium azolate, metronidazole and sulfasalazine respectively. One case reported here is caused by 5-ASA (mesalazine). Case patient male, 34 years old. Due to lower abdominal pain, diarrhea and weight loss and admission. Colonoscopy and biopsy histologically confirmed Crohn’s disease. Patients without upper abdominal pain, no abnormal physical examination, given mesalazine