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目的探讨神经降压素对大鼠应激性胃溃疡的影响及与表皮生长因子的关系。方法采用脑室微量注射和放射免疫分析方法，观察神经降压素对应激性胃溃疡的影响和胃粘膜组织中表皮生长因子含量的变化。结果在大鼠应激性胃溃疡产生时，血浆表皮生长因子含量显著增高（Ｐ＜０．０１）；侧脑室注射神经降压素，大鼠应激性胃溃疡的产生明显减轻（Ｐ＜０．０１），同时血浆及胃粘膜组织中表皮生长因子的含量显著增加（Ｐ＜０．０１）。结论神经降压素具有保护胃粘膜细胞的作用，该保护作用可能与表皮生长因子含量的改变有关。
Objective To investigate the effect of neurotensin on stress ulcer in rats and its relationship with epidermal growth factor. Methods The effects of neurotensin on gastric ulcer and epidermal growth factor in gastric mucosa were observed by microinjection of ventricle and radioimmunoassay. Results The level of plasma epidermal growth factor (EGF) was significantly increased in rats with stress ulcer (P <0.01). The neurotoxicity of neurotensin in the lateral ventricle was significantly reduced (P <0 .01). Meanwhile, the content of epidermal growth factor in plasma and gastric mucosa significantly increased (P <0.01). Conclusion Neurotensin can protect gastric mucosal cells, which may be related to the changes of epidermal growth factor.