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［目的］探讨ｎｍ２３－Ｈ１及ＣＤ４４ｖ６在非小细胞肺癌中表达的意义及与预后的联系。［方法］用免疫组织化学ＬＳＡＢ染色法，研究８４例非小细胞肺癌中ｎｍ２３－Ｈ１及ＣＤ４４ｖ６的表达及与淋巴结转移的关系。［结果］５９．６％的腺癌和５４．１％的鳞癌有ｎｍ２３－Ｈ１的表达；在有淋巴结转移的肺癌中ｎｍ２３－Ｈ１表达的阳性率为２１．９％，而无淋巴结转移的肺癌中其表达率高达７８．８％，两者差异具非常显著性。５３．２％的腺癌和５６．７％的鳞癌有ＣＤ４４ｖ６的表达；在有淋巴结转移的肺癌中ＣＤ４４ｖ６表达的阳性率为９６．９％，而无淋巴结转移的肺癌中其表达率仅为２８．８％，两者差异具非常显著性。［结论］ｎｍ２３－Ｈ１的表达与非小细胞肺癌的淋巴结转移呈负相关，ＣＤ４４ｖ６的表达与非小细胞肺癌的淋巴结转移呈正相关，参与和调节淋巴结的转移过程，是观察预后的重要指标，对于非小细胞肺癌的预后有重要意义。
[Objective] To explore the significance of nm23-H1 and CD44v6 expression in non-small cell lung cancer and its relationship with prognosis. [Methods] The expression of nm23-H1 and CD44v6 and its relationship with lymph node metastasis were studied in 84 cases of non-small cell lung cancer by immunohistochemical staining with LSAB. [Results] The expression of nm23-H1 was detected in 59.6% of adenocarcinomas and 54.1% of squamous cell carcinomas. The positive rate of nm23-H1 expression in lung cancer with lymph node metastasis was 21.9%, but no lymph node metastasis. The expression rate in lung cancer was as high as 78.8%, and the difference was very significant. 53.2% of adenocarcinomas and 56.7% of squamous cell carcinomas had CD44v6 expression; in patients with lymph node metastases, the positive rate of CD44v6 expression was 96.9%, but in lung cancer without lymph node metastasis, the expression rate was only 28.8%, the difference between the two is very significant. [Conclusion] The expression of nm23-H1 was negatively correlated with the lymph node metastasis of non-small cell lung cancer. The expression of CD44v6 was positively correlated with the lymph node metastasis of non-small cell lung cancer. Participating in and regulating the metastasis of lymph nodes was an important indicator of prognosis. The prognosis of non-small cell lung cancer is of great significance.