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目的观察辛伐他汀联合仙灵葆胶囊治疗骨质疏松症的临床效果。方法选择2008年3月—2011年3月收治的骨质疏松症患者120例,随机分为对照组与治疗组各60例。对照组予以仙灵骨葆胶囊,3粒/次、2次/d,口服。治疗组在对照组基础上加服辛伐他汀20 mg/d,1次/d,口服。30 d为一个疗程,两组均服药3个疗程。观察两组治疗前及治疗3个月后骨密质的变化,采用双级X线骨密度仪测量腰椎、股骨颈骨密度;比较两组疼痛视觉模拟评分法(visual analogue scale,VAS)评分;比较两组治疗前后血清降钙素、碱性磷酸酶的生化指标的变化;比较综合疗效。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗后,对照组骨密度、疼痛VAS评分分别为(0.583±0.029)g/cm2、(6.694±3.202)分,治疗组分别为(0.630±0.089)g/cm2、(3.552±2.004)分,两组比较差异均有统计学意义(均P<0.05)。对照组血清降钙素、碱性磷酸酶分别为(12.824±3.984)mg/L、(64.445±15.390)U/L,治疗组分别为(10.927±2.521)mg/L、(73.617±17.847)U/L,两组比较差异均有统计学意义(均P<0.05)。对照组总有效率56.67%,治疗组93.33%,两组总有效率比较差异有统计学意义(P<0.05)。结论辛伐他汀联合仙灵骨葆胶囊用于骨质疏松症,疗效确切,可增强骨质密度而降低骨折的危险,值得临床推广应用。
Objective To observe the clinical effect of Simvastatin combined with Xianlingbao capsule in the treatment of osteoporosis. Methods 120 cases of osteoporosis admitted from March 2008 to March 2011 were randomly divided into control group and treatment group with 60 cases each. Control group to Xianling Gubao capsule, 3 capsules / time, 2 times / d, orally. The treatment group was given simvastatin 20 mg / d on the basis of the control group once a day orally. 30 d for a course of treatment, two groups were taking 3 courses. The changes of bone mass before and 3 months after treatment were observed. The bone mineral density of lumbar and femoral neck was measured by two-stage X-ray absorptiometry. The visual analogue scale (VAS) score was compared between the two groups. The changes of serum biochemical indexes of calcitonin and alkaline phosphatase in the two groups before and after treatment were compared. The comprehensive curative effect was compared. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results After treatment, the bone mineral density and pain VAS scores in the control group were (0.583 ± 0.029) g / cm2 and (6.694 ± 3.202), respectively, and were 0.630 ± 0.089 g / cm2 and 3.552 ± 2.004 in the control group, The differences between the two groups were statistically significant (P <0.05). The levels of serum calcitonin and alkaline phosphatase in the control group were (12.824 ± 3.984) mg / L and (64.445 ± 15.390) U / L, respectively, and were 10.927 ± 2.521 mg / L and 73.617 ± 17.847 U / L, the difference between the two groups was statistically significant (P <0.05). The total effective rate was 56.67% in the control group and 93.33% in the treatment group. The total effective rate was significantly different between the two groups (P <0.05). Conclusion Simvastatin combined with Xianling Gubao capsule for osteoporosis, curative effect is exact, can increase bone density and reduce the risk of fractures, it is worth to clinical application.