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目的探讨与比较全胃切除术与近端胃切除术治疗胃上部癌的疗效。方法收集我院2013年4月~2015年9月入院的50例需行切除术的胃上部癌患者随机为两组。全胃组患者采取全胃切除术，近端组患者采取近端胃切除术，比较两组患者围手术期相关临床指标与并发症。结果两组患者术中出血量、手术时间、排气时间与住院时间不存在明显差异，不具有统计学意义（>0.05）；近端组患者反流性食管炎发生率明显高于对照组，存在明显差异，具有统计学意义（0.05）。结论近端胃切除术与全胃切除术效果相当，但近端胃切除术反流性食管炎的发生率较高，具有一定危险性，故而优先选择全胃切除术，具有借鉴性。“,”Objective To investigate and compare the therapeutic effect of total gastrectomy and proximal gastrectomy for gastric cancer.Methods 50 patients with gastric cancer who were admitted to our hospital from April 2013 to September 2015 were randomly assigned to two groups. A full stomach patients take total gastrectomy and proximal groups were taken to the proximal gastrectomy, compared two groups of patients with peri operative clinical parameters and complications.Results There was no significant difference between the two groups in the amount of bleeding, operation time, exhaust time and hospitalization time, and there was no statistical significance ( >0.05); the incidence of reflux esophagitis in the proximal group was significantly higher than that in the control group, with statistical significance ( 0.05).Conclusion Proximal gastrectomy and total gastrectomy for effect, but the proximal gastrectomy reflux esophagitis incidence of higher, with some risk, and therefore preferred option total gastrectomy, which is a reference.